Effects of Prednisolone and Kotase on Post-Disimpaction Sequelae of Mandibular Third Molars in General Hospital, Lagos: A Randomized Controlled Trial
DOI:
https://doi.org/10.61172/5mtab048Keywords:
Third molar, multiple impaction, diabetics, hypertensive, Prednisolone, KotaseAbstract
Background
The sequelae of surgical disimpaction of mandibular third molars negatively impact patients' quality of life in the immediate post-operative period. Some clinicians have shown reluctance to use steroids in oral surgery, though they provide excellent control of the postoperative inflammatory triad following third molar disimpaction. Kotase, a fixed-dose combination of two enzymes (Bromelain and Trypsin), has also been effective in reducing postoperative inflammation.
Methods
We conducted a randomized controlled trial at the General Hospital, Lagos Island. Eighty-four participants were randomized into two treatment groups: Prednisolone and Kotase. Pain was assessed using a visual analogue scale (VAS). Facial swelling was measured using linear distances from the tragus to pogonion, tragus to the angle of the mouth, and gonial angle to the lateral canthus of the eye. Trismus was measured using a pair of dividers. Data were analyzed using SPSS version 20. Chi-square and Student's t-tests were used for comparisons, with p < 0.05 considered significant.
Results
The socio-demographic and clinical characteristics of participants were similar in both groups. The highest intensity of sequelae occurred on the first postoperative day in both groups. Pain was not statistically significant (t = 0.067, p = 0.946). Facial volumetric variation in the tragus–oral commissure plane (t = 0.369, p = 0.713), tragus–pogonion plane (t = 0.959, p = 0.341), and outer canthus–gonial plane (t = 1.523, p = 0.132) showed no significant differences. Trismus was also not statistically significant (t = 0.890, p = 0.376).
Conclusion
Kotase was observed to be as effective as prednisolone in mitigating postoperative inflammatory sequelae following mandibular third molar disimpaction
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Copyright (c) 2025 Babalola Oluwole Castano, Akanbi Clement .O Oluwarotimi, Oluwafemi Adewale Adesina, Bola Obisesan, Olalekan Michael Gbotolorun, Adeshina Olumuyiwa S Ayodele
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