Articles Gold Open Access (CC BY 4.0) Published: 24-06-2023 1,615 Views 344 Downloads

Oral Leukoplakia

MALIGNANT TRANSFORMATION OF ORAL LEUKOPLAKIA TO SQUAMOUS CELL CARCINOMA IN AN HIV PATIENT: A CASE REPORT

Okoh M ( University of Benin Teaching Hospital )
Izegboya Ukpebor ( University of Benin Teaching Hospital )
Nwauzor ES ( University of Benin Teaching Hospital )
DOI: https://doi.org/10.61172/ndj.v30i2.225
Issue: Vol. 30 No. 2 (2022): Nigerian Dental Journal

Abstract

Oral leukoplakia is a potentially malignant lesion and most oral squamous cell carcinomas occur on the background of oral leukoplakia. The risk of malignant transformation increases with immunosuppressive states. Regular monitoring of patient is very important for early detection of any mucosal and dysplastic changes. This will aid early intervention and improve patient’s survival.

Keywords (MeSH)

Oral leukoplakia Potentially malignant malignant transformation

Author Biographies

Okoh M — University of Benin Teaching Hospital

Head of Department

Department of Oral pathology and medicine, University of Benin Teaching Hospital.

 

Nwauzor ES — University of Benin Teaching Hospital

Senior Registrar ,  Department of Oral Pathology and medicine, University of Benin Teaching Hospital, Benin city, Edo State.

References

  1. REFERENCES
  2. Hong WK, Hittelman WN, Mao L, et al. Predicting cancer development in oral leukoplakia: ten years of translational research. Clinical Cancer Research. Published 2000.
  3. Warnakulasuriya S, Johnson NW, Van Der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 2007;36(10):575-580. doi:10.1111/J.1600-0714.2007.00582.X
  4. Jennifer H. Leukoplakia: Symptoms, causes, and prevention. Published 2019. Accessed February 10, 2023. https://www.medicalnewstoday.com/articles/317689
  5. Vlad R, Panainte I, Stoica A, Monea M. The Prevalence of Oral Leukoplakia: Results From a Romanian Medical Center. Eur Sci Journal, ESJ. 2016;12(27):12. doi:10.19044/esj.2016.v12n27p12
  6. Ha PK, Pilkington TA, Westra WH, Sciubba J, Sidransky D, Califano JA. Progression of microsatellite instability from premalignant lesions to tumors of the head and neck. Int J cancer. 2002;102(6):615-617. doi:10.1002/IJC.10748
  7. Shiu MN, Chen THH, Chang SH, Hahn LJ. Risk factors for leukoplakia and malignant transformation to oral carcinoma: a leukoplakia cohort in Taiwan. Br J Cancer. 2000;82(11):1871-1874. doi:10.1054/BJOC.2000.1208
  8. Erugula S, Umar Farooq M, Jahagirdar D, Srija C, Meruva S, Venkata G. Oral Leukoplakia Etiology , Risk Factors , Molecular Pathogenesis , Prevention and Treatment : A Review. Int J Contemp Med Res. 2020;7(11):5-9.
  9. Warnakulasuriya S, Ariyawardana A. Malignant transformation of oral leukoplakia: a systematic review of observational studies | Request PDF. J oral Pathol Med. 2019;45(155).
  10. Weber M, Wehrhan F, Baran C, et al. Malignant transformation of oral leukoplakia is associated with macrophage polarization. J Transl Med. 2020;18(1):1-18. doi:10.1186/S12967-019-02191-0/TABLES/4
  11. Attar E, Dey S, Hablas A, et al. Head and Neck Cancer in a Developing Country: A Population-Based Perspective Across 8 Years. Oral Oncol. 2010;46(8):591. doi:10.1016/J.ORALONCOLOGY.2010.05.002
  12. Sudbø J, Reith A. Which putatively pre-malignant oral lesions become oral cancers? Clinical relevance of early targeting of high-risk individuals. J Oral Pathol Med. 2003;32(2):63-70. doi:10.1034/J.1600-0714.2003.00054.X
  13. Sun Z, Gong Y, Huang J. Analysis of relationship between risk factors of malignant transformation of oral leukoplakia and the LSCP system. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology. Published 2001.
  14. Aguirre-Urizar JM, Lafuente-Ibáñez de Mendoza I, Warnakulasuriya S. Malignant transformation of oral leukoplakia: Systematic review and meta-analysis of the last 5 years. Oral Dis. 2021;27(8):1881-1895. doi:10.1111/ODI.13810
  15. Waal I. Oral Leukoplakia : Present Views on Diagnosis , Management , Communication with Patients , and Research. Published online 2019:9-13.
  16. Amagasa T, Yamashiro M, Ishikawa H. Oral Leukoplakia Related to Malignant Transformation. Oral Sci Int. 2006;3(2):45-55. doi:10.1016/S1348-8643(06)80001-7
  17. Barfi Qasrdashti A, Habashi MS, Arasteh P, Ardakani MT, Abdoli Z, Eghbali S. Malignant Transformation in Leukoplakia and Its Associated Factors in Southern Iran: A Hospital Based Experience. Iran J Public Heal. 2017;46(8):1110-1117.
  18. Castagnola P, Malacarne D, Scaruffi P, Maffei M, Donadini A. Chromosomal aberrations and aneuploidy in oral potentially malignant lesions : distinctive features for tongue. BMC Cancer. 2011;11(1):445. doi:10.1186/1471-2407-11-445
  19. Bettendorf O, Piffkò J, Bànkfalvi A. Prognostic and predictive factors in oral squamous cell cancer: important tools for planning individual therapy? Oral Oncol. 2004;40(2):110-119. doi:10.1016/J.ORALONCOLOGY.2003.08.010
  20. Baykul T, Yilmaz HH, Aydin Ü, Aydin MA, Aksoy MÇ, Yildirim D. Early diagnosis of oral cancer. J Int Med Res. 2010;38(3):737-749. doi:10.1177/147323001003800302

Similar Articles

1-10 of 130

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)