Pattern of Oral and Maxillofacial Biopsy Results in a Teaching Hospital; An 11-year Retrospective Study
DOI:
https://doi.org/10.61172/v5k2rw36Keywords:
Biopsy, benign, malignant, odontogenic tumour, carcinomaAbstract
Background
Biopsy remains a cornerstone in diagnostic pathology, enabling definitive diagnosis, guiding treatment planning, and informing tumor classification. This study evaluated the distribution of histopathologically diagnosed lesions in the oral and maxillofacial region over an 11-year period.
Methods
A retrospective review was conducted at the Department of Oral and Maxillofacial Surgery, Oral Pathology, and Molecular Biology, Lagos University Teaching Hospital, Nigeria. Biopsy records from January 2013 to December 2023 were analyzed. Ethical approval was obtained from the Health Research and Ethics Committee (HREC Approval No. ADM/DSCST/HREC/APP/5714).
Results
A total of 756 biopsies were reviewed. Females accounted for 52.2% of cases. The highest frequency of tumors occurred in the fourth decade of life (20.8%). Odontogenic tumors were the most prevalent lesion group, with ameloblastoma being the most common histologic diagnosis, predominantly involving the mandible.
Conclusion
A broad spectrum of lesions affects the maxillofacial region. Biopsy remains indispensable for definitive diagnosis. Knowledge of lesion distribution patterns is vital for clinical decision-making among oral surgeons and pathologists.
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References
1. Hosgor H, Tokuc B, Coskunses FM. Evaluation of biopsies of oral and maxillofacial lesions: a retrospective study. J Korean Assoc Oral Maxillofac Surg 2019;45:316-323.
2. Navin S, Viren A, Amit M, Nishita S, Rishabh S, Sonal S. Clinical Evaluation of Scalpel Blades Biopsy and Punch Biopsy of Oral Mucosal lesion for Histopathology. Saudi J Oral Dent Res. 2021;6(7):286-291.
3. Fareedi MA, Prasant MC, Ashok P, Vinit A, Safiya T, Kishor P, Rashmi D. Oral Biopsy in General Dental Practice: A Review. Int. J. Med. Public Health. 2012;2(1):10-13.
4. Amparo MR, Francisco JS, Juan MS. Oral biopsy in dental practice. Med Oral Patol Oral Cir Bucal. 2007;12(7):504-10.
5. Gbolahan OO, Lawal AO, Akinyamoju CA. Clinical and histological diagnosis of oral pathologic lesions, any concordance? Afr. J. Oral Health. 2019;8(2):48-54.
6. Ajit VK, Renuka N, Kadre AS, Sadaf S, Rehan B, Shah A. Most Common Oral Lesions Found in Biopsy: A Three-Years Retrospective Analysis. IJDMSR. 2024;6(1):439-450.
7. Prasant MC, Anuroop S, Ashutosh DP, Fareedi MA. Focus on basic principles of biopsy: A review. Merit Res. J. Med. Med. Sci. 2014;2(1):1-6.
8. Varsha RSJ, Frankantony PB. Biopsy- an overview. WJPLS. 2017;3(10):37-39.
9. Singh H, Poonia M, Sidhu SK, Sihmar SS. Biopsy- A vision of life. IJCMR. 2016;3(6):17347.
10. Massoumeh Z. A Review of Biopsy in Dentistry: Principles, Techniques, and Considerations. J Dent Mater Tech. 2014;3(2):47-54.
11. Soluk-Tekkesin M, Wright JM. The World Health Organization Classification of Odontogenic Lesions: A Summary of the Changes of the 2022 (5th) Edition. Turk Patoloji Derg. 2022;38(2):168-84.
12. Ramesh K, Maya R, George P. Retrospective Evaluation of Pediatric Oral Biopsies from A Dental and Maxillofacial Surgery Centre in Salem, Tamil Nadu, India. JCDR. 2014;8(1):221-223.
13. Vhriterhire RA, Osamudiamen JO. Review of oral and maxillofacial biopsies in a tertiary hospital in Nigeria. Highland Med Res J. 2021;21(2):42-46.
14. Leigh O, Akinyamoju AO, Ogun GO, Okoje VN. Spectrum of oral and maxillofacial tissue biopsies at the foremost tertiary institution in The Gambia: A retrospective review. J West Afr Coll Surg. 2023;13:1-5.
15. Odukoya O. Odontogenic tumors: Analysis of 289 Nigerian cases. J Oral Pathol Med. 1995;24(10):45-47.
16. Adebayo ET, Ajike SO, Adekeye EO. A review of 318 odontogenic tumors in Kaduna, Nigeria. J Oral Maxillofac Surg. 2005;63(6):811-819.
17. Mahsa K, Aida AS. A Survey of Oral and Maxillofacial Biopsies Over a 23-year Period in the Southeast of Iran. J Dent Shiraz Univ Med Sci. 2022;23(3):298-306.
18. Thompson AE, Anisimowicz Y, Miedema B, Hogg W, Wodchis WP, Aubrey-Bassler K. The influence of sex and other patient characteristics on health care-seeking behaviour: AQUALICOPC study. BMC Fam Pract. 2016;17(1):17.
19. Muwonge R, Ramadas K, Sankila R, Thara S, Thomas G, Vinoda J, et al. Role of tobacco smoking, chewing and alcohol drinking in the risk of oral cancer in Trivandrum, India: A nested case-control design using incident cancer cases. Oral Oncol. 2008;44(5):446-454.
20. Kamulegeya A, Kalyanyama BM. Oral maxillofacial neoplasms in an East African population: a 10-year retrospective study of 1863 c a s e s using histopathological reports. BMC Oral Health. 2008;8(1):11.
21. Jing W, Xuan M, Lin Y, Wu L, Liu L, Zheng X, et al. Odontogenic tumors: a retrospective study of 1642 cases in a Chinese population. Int J Oral Maxillofac Surg. 2007;36(1):20–25.
22. Sekerci AE, Nazlım S, Etoz M, Denız K, Yasa Y. Odontogenic tumors: A collaborative study of 218 cases diagnosed over 12 years and comprehensive review of the literature. Med Oral Patol Oral Cir Bucal. 2015;20(1):34-44.
23. Akinosi JO, Williams AO. Ameloblastoma in Ibadan, Nigeria. Oral Surgery, Oral Med Oral Pathol. 1969;27(2):257-265.
24. Akinmoladun V, Udeabor S, Arotiba J. Pattern of odontogenic tumors in Nigeria: a review of the literature. Niger Dent J. 2011;18(1):28-32.
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Copyright (c) 2025 Ebrorhie Ochuko, Adeyemi O. Michael, Abdullahi A.S. Mohammed, Ngalato F. Haningh, Okwor G. Chiamaka, Adedire O. Adetomiwa, Ajayi F. Oluseyi
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